| | Randomized phase IIb trial of a CMV vaccine immunotherapeutic candidate (VBI-1901) in recurrent glioblastomas
Conference: 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
Date: June 1, 2024
| Glioblastoma | View Press Release | glioblastoma |
| | Peripheral Biomarker Analysis of T Cell-Mediated Collagen Remodeling Correlates With Tumor Responses in a Phase IIa Trial of Vaccine Immunotherapeutic Candidate (VBI-1901)
Conference: 2023 Society for Neuro-Oncology (SNO) Annual Meeting
Date: November 17, 2023
| Glioblastoma | View Press Release | glioblastoma |
| | T-cell responses to Pre-S1 and Pre-S2 are correlated to anti-HBs antibody titers, which are higher and persist longer in volunteers vaccinated with 3-antigen than with 1-antigen hepatitis B vaccine in the PROTECT Study: 3.5 year follow up
Conference: Annual Meeting of the European Association for the Study of the Liver (EASL) 2023
Date: June 21, 2023
| Hepatitis B | View Press Release | hepatitis-b |
| | New 3-Antigen HBV Vaccine With Pre-S1 and Pre-S2 for Adults Induces a High Immune Response and Long Term Persistence of Anti-HBs Antibodies in Adults
Conference: 33rd European Congress of Clinical Microbiology and Infectious Diseases (EECMID)
Date: April 18, 2023
| Hepatitis B | | hepatitis-b |
| | Comprehensive Biomarker Analysis of Responders and Non-Responders in a Phase IIa Trial of a CMV Vaccine Immunotherapeutic Candidate (VBI-1901)
Conference: 2022 Society for Neuro-Oncology (SNO) Annual Meeting
Date: November 18, 2022
| Glioblastoma | View Press Release | glioblastoma |
| | Therapeutic vaccination of chronically HBV infected patients with low-level of HBsAg using a combination of a third generation PreS/S vaccine (Sci-B-Vac™) and a nucleoside analogue
Conference: 2022 International HBV Meeting
Date: September 19, 2022
| Hepatitis B | View Press Release | hepatitis-b |
| | Evaluation of tumor responses and overall survival in recurrent glioblastoma (GBM) patients from a Phase IIa trial of a CMV vaccine immunotherapeutic candidate (VBI-1901)
Conference: 2022 American Society of Clinical Oncology (ASCO) Annual Meeting
Date: June 6, 2022
| Glioblastoma | View Press Release | glioblastoma |
| | Cost-effectiveness of 3-Antigen vs. Single-Antigen Vaccine for Prevention of Hepatitis B in Adults in the United States
Conference: The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) 2022 Annual Conference
Date: May 18, 2022
| Hepatitis B | View Press Release | hepatitis-b |
| | Cell-mediated and humoral immune responses after vaccination with a 3-antigen HBV vaccine containing pre-S1, pre-S2, and S antigens, compared to a single-antigen HBV vaccine: Results from a pivotal phase III, randomized clinical trial (PROTECT)
Conference: American Association for the Study of Liver Disease (AASLD) – The Liver Meeting® 2021
Date: November 12, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | Lower non-response rates to 3-antigen HBV vaccine among adults with diabetes, age ≥ 45, or obesity compared to a single-antigen HBV vaccine: PROTECT STUDY
Conference: American Diabetes Association’s Virtual 81st Scientific Sessions
Date: June 25, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | Restoration of HBV-specific immune responses with therapeutic vaccine BRII-179 (VBI-2601) in chronic HBV patients in a phase 1b/2a study
Conference: Annual Meeting of the European Association for the Study of the Liver (EASL) 2021
Date: June 23, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | A 3-antigen prophylactic hepatitis B virus vaccine confers rapid onset of protection in young adults, age 18-45, compared to a single-antigen hepatitis B virus vaccine
Conference: Annual Meeting of the European Association for the Study of the Liver (EASL) 2021
Date: June 23, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | Robust Immunogenicity and Rapid Onset of High Rates of Seroprotection and Anti-HBs Titers, Elicited with 3-Antigen Hepatitis B Vaccine in Adults
Conference: 2021 International Symposium on Viral Hepatitis and Liver Disease (ISVHLD)
Date: June 18, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | Evaluation of GM-CSF and AS01B Adjuvants in a Phase I/IIa Trial of a Therapeutic CMV Vaccine (VBI-1901) Against Recurrent Glioblastoma (GBM)
Conference: 2021 American Society of Clinical Oncology (ASCO) Annual Meeting
Date: June 8, 2021
| Glioblastoma | View Press Release | glioblastoma |
| | Higher seroprotection rates (SPR) and higher anti-HBs concentrations in adults age 18-45 immunized with 3-antigen hepatitis B vaccine (3A-HBV) compared to 1-antigen hepatitis B vaccine (1A-HBV): Results from the pivotal, double-blind, randomized Phase 3 study (CONSTANT)
Conference: Canadian Liver Meeting 2021
Date: May 5, 2021
| Hepatitis B | View Press Release | hepatitis-b |
| | Identification of a baseline biomarker associated with tumor responses in a Phase I/Iia trial of a therapeutic CMV vaccine against recurrent glioblastoma (GBM)
Conference: 2020 Annual Meeting of the Society for Neuro-Oncology (SNO)
Date: November 19, 2020
| Glioblastoma | View Press Release
Watch Video | glioblastoma |
| | A 3-antigen hepatitis B vaccine provides consistently higher seroprotection rates (SPR) and anti-HBs titers compared to single-antigen vaccine in adults with comorbidities known to be associated with poor response to vaccinations: Results from the phase III double-blind, randomized study (PROTECT)
Conference: American Association for the Study of Liver Disease (AASLD) – The Liver Meeting® 2020
Date: November 13, 2020
| Hepatitis B | View Press Release | hepatitis-b |
| | Rapid onset of seroprotection rates in young adults immunized with a 3-antigen hepatitis B virus (HBV) vaccine compared to a single-antigen HBV vaccine
Conference: IDWeek 2020™
Date: October 26, 2020
| Hepatitis B | View Press Release | hepatitis-b |
| | Higher hepatitis B antibody titers induced in all adults vaccinated with a 3-antigen hepatitis B (HBV) vaccine, compared to a single-antigen HBV vaccine: Results from two pivotal phase 3 double-blind, randomized studies (PROTECT and CONSTANT)
Conference: IDWeek 2020™
Date: October 26, 2020
| Hepatitis B | View Press Release | hepatitis-b |
| | TCR and HLA analysis of patients in a Phase I/Iia trial of a therapeutic CMV vaccine against recurrent glioblastoma (rGBM)
Conference: The European Society for Medical Oncology (ESMO) Virtual Congress 2020
Date: September 17, 2020
| Glioblastoma | View Press Release | glioblastoma |
| | Higher proportion of responders with hepatitis B antibody levels ≥ 100 mIU/mL with the tri-antigenic HepB vaccine, Sci-B-Vac®, compared to Engerix-B®: Results from the phase 3 double-blind, randomized study comparing immunogenicity and safety (PROTECT)
Conference: The Digital International Liver Congress™ 2020 (ILC) – the Annual Meeting of the European Association for the Study of the Liver (EASL)
Date: August 31, 2020
| Hepatitis B | View Press Release | hepatitis-b |
| | CMV-specific immuno-dyregulation in recurrent glioblastoma patients can be overcome with therapeutic vaccineation which is associated with tumor response and overall survival benefits in a Phase I/Iia study
Conference: 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting II
Date: June 22, 2020
| Glioblastoma | View Press Release
Watch Video | glioblastoma |
| | Interim results of the extension phase of a Phase I/IIa trial of a therapeutic CMV vaccine against recurrent glioblastoma (GBM)
Conference: 2019 Annual Meeting of the Society for Neuro-Oncology (SNO)
Date: November 22, 2019
| Glioblastoma | View Press Release | glioblastoma |
| | Rapid increase in anti-HBsAg titers and higher seroprotection rates in adults immunized with Sci-B-Vac® compared to a monovalent hepatitis B vaccine: Results from PROTECT – a double-blind, randomized, controlled, Phase 3 study
Conference: American Association for the Study of Liver Disease (AASLD) – The Liver Meeting® 2019
Date: October 22, 2019
| Hepatitis B | View Press Release | hepatitis-b |
| | CMV gB/pp65 eVLPs formulated with GM-CSF as a therapeutic vaccine against recurrent GBM
Conference: 2019 American Society of Clinical Oncology (ASCO) Annual Meeting
Date: June 4, 2019
| Glioblastoma | View Press Release | glioblastoma |
| | High seroprotection rates achieved with two doses of Sci-B-Vac, a third-generation hepatitis B vaccine containing Pre-S1, Pre-S2, and S antigens
Conference: 2019 Annual Meeting of the European Association for the Study of the Liver (EASL)
Date: April 9, 2019
| Hepatitis B | View Press Release | hepatitis-b |
| | CMV gB/pp65 eVLPs formulated with GM-CSF as a therapeutic vaccine against recurrent GBM
Conference: 2018 Annual Meeting of the Society for Neuro-Oncology (SNO)
Date: October 24, 2018
| Glioblastoma | View Press Release | glioblastoma |